Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival

Ischemia-reperfusion injury (IRI) amplifies T cell alloimmune responses after transplantation with thrombin playing a key pro-inflammatory role. To explore the influence of thrombin on regulatory T cell recruitment and efficacy we used a well-established model of IRI in the native murine kidney. Adm...

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Detalles Bibliográficos
Autores principales: Peng, Qi, Nowocin, Anna, Ratnasothy, Kulachelvy, Smith, Richard A., Smyth, Lesley A., Lechler, Robert I., Dorling, Anthony, Lombardi, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924086/
https://www.ncbi.nlm.nih.gov/pubmed/36793549
http://dx.doi.org/10.3389/fimmu.2022.980462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924086/
https://www.ncbi.nlm.nih.gov/pubmed/36793549
http://dx.doi.org/10.3389/fimmu.2022.980462

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