Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

[Image: see text] Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination with ritonavir, is used to treat infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Nirmatrelvir interrupts the viral life cycle by inhibiting the SARS-CoV-2 main...

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Detalles Bibliográficos
Autores principales: Brewitz, Lennart, Dumjahn, Leo, Zhao, Yilin, Owen, C. David, Laidlaw, Stephen M., Malla, Tika R., Nguyen, Dung, Lukacik, Petra, Salah, Eidarus, Crawshaw, Adam D., Warren, Anna J., Trincao, Jose, Strain-Damerell, Claire, Carroll, Miles W., Walsh, Martin A., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924091/
https://www.ncbi.nlm.nih.gov/pubmed/36757959
http://dx.doi.org/10.1021/acs.jmedchem.2c01627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924091/
https://www.ncbi.nlm.nih.gov/pubmed/36757959
http://dx.doi.org/10.1021/acs.jmedchem.2c01627

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