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Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
To better understand clonal and transcriptional adaptations after relapse in patients with acute myeloid leukemia (AML), we collected presentation and relapse samples from six normal karyotype AML cases. We performed enhanced whole-genome sequencing to characterize clonal evolution, and deep-coverag...
Autores principales: | Petti, Allegra A., Khan, Saad M., Xu, Ziheng, Helton, Nichole, Fronick, Catrina C., Fulton, Robert, Ramakrishnan, Sai M., Nonavinkere Srivatsan, Sridhar, Heath, Sharon E., Westervelt, Peter, Payton, Jacqueline E., Walter, Matthew J., Link, Daniel C., DiPersio, John, Miller, Christopher, Ley, Timothy J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924296/ https://www.ncbi.nlm.nih.gov/pubmed/35019859 http://dx.doi.org/10.1158/2643-3230.BCD-21-0050 |
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