Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability

FGFR3-TACC3 represents an oncogenic fusion protein frequently identified in glioblastoma, lung cancer, bladder cancer, oral cancer, head and neck squamous cell carcinoma, gallbladder cancer, and cervical cancer. Various exon breakpoints of FGFR3-TACC3 have been identified in cancers; these were anal...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Clark G., Peiris, Malalage N., Meyer, April N., Nelson, Katelyn N., Donoghue, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924825/
https://www.ncbi.nlm.nih.gov/pubmed/36780330
http://dx.doi.org/10.18632/oncotarget.28359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924825/
https://www.ncbi.nlm.nih.gov/pubmed/36780330
http://dx.doi.org/10.18632/oncotarget.28359

Ejemplares similares