P2Y(6) receptor‐dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging

Aging causes loss of brain synapses and memory, and microglial phagocytosis of synapses may contribute to this loss. Stressed neurons can release the nucleotide UTP, which is rapidly converted into UDP, that in turn activates the P2Y(6) receptor (P2Y(6)R) on the surface of microglia, inducing microg...

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Detalles Bibliográficos
Autores principales: Dundee, Jacob M., Puigdellívol, Mar, Butler, Richard, Cockram, Thomas O. J., Brown, Guy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924939/
https://www.ncbi.nlm.nih.gov/pubmed/36565471
http://dx.doi.org/10.1111/acel.13761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924939/
https://www.ncbi.nlm.nih.gov/pubmed/36565471
http://dx.doi.org/10.1111/acel.13761

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