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P2Y(6) receptor‐dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging
Aging causes loss of brain synapses and memory, and microglial phagocytosis of synapses may contribute to this loss. Stressed neurons can release the nucleotide UTP, which is rapidly converted into UDP, that in turn activates the P2Y(6) receptor (P2Y(6)R) on the surface of microglia, inducing microg...
Autores principales: | Dundee, Jacob M., Puigdellívol, Mar, Butler, Richard, Cockram, Thomas O. J., Brown, Guy C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924939/ https://www.ncbi.nlm.nih.gov/pubmed/36565471 http://dx.doi.org/10.1111/acel.13761 |
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