Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor

Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature to caloric restriction and identified rilmenidine, an I1‐imidazoline receptor agonist and...

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Detalles Bibliográficos
Autores principales: Bennett, Dominic F., Goyala, Anita, Statzer, Cyril, Beckett, Charles W., Tyshkovskiy, Alexander, Gladyshev, Vadim N., Ewald, Collin Y., de Magalhães, João Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924948/
https://www.ncbi.nlm.nih.gov/pubmed/36670049
http://dx.doi.org/10.1111/acel.13774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924948/
https://www.ncbi.nlm.nih.gov/pubmed/36670049
http://dx.doi.org/10.1111/acel.13774

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