Cargando…

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor

Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature to caloric restriction and identified rilmenidine, an I1‐imidazoline receptor agonist and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bennett, Dominic F., Goyala, Anita, Statzer, Cyril, Beckett, Charles W., Tyshkovskiy, Alexander, Gladyshev, Vadim N., Ewald, Collin Y., de Magalhães, João Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924948/ https://www.ncbi.nlm.nih.gov/pubmed/36670049 http://dx.doi.org/10.1111/acel.13774

Ejemplares similares

Longevity interventions temporally scale healthspan in Caenorhabditis elegans
por: Statzer, Cyril, et al.
Publicado: (2022)

Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans
por: Wang, Lixin, et al.
Publicado: (2022)

Polygonati Rhizoma Polysaccharide Prolongs Lifespan and Healthspan in Caenorhabditis elegans
por: Luan, Yage, et al.
Publicado: (2023)

Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans
por: Lin, Chunxiu, et al.
Publicado: (2019)

Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan
por: Duangjan, Chatrawee, et al.
Publicado: (2021)

Ingestion of single guide RNAs induces gene overexpression and extends lifespan in Caenorhabditis elegans via CRISPR activation
por: Fischer, Fabian, et al.
Publicado: (2022)

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans
por: Li, Pan, et al.
Publicado: (2021)

Immobilization of Superoxide Dismutase in Mesoporous Silica and its Applications in Strengthening the Lifespan and Healthspan of Caenorhabditis elegans
por: Yang, Yiling, et al.
Publicado: (2022)

SERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegans
por: Romero-Sanz, Silvia, et al.
Publicado: (2023)

The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification
por: Teuscher, Alina C., et al.
Publicado: (2019)

The non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake
por: Gupta, Swati, et al.
Publicado: (2022)

CRISPR-activated expression of collagen col-120 increases lifespan and heat tolerance
por: Goyala, Anita, et al.
Publicado: (2023)

Lifespan-Associated Gene Expression Signatures of Recombinant BXD Mice Implicates Coro7 and Set in Longevity
por: Vitiello, David, et al.
Publicado: (2021)

SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans
por: Pandey, Renu, et al.
Publicado: (2018)

Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1
por: Dong, Zhenghan, et al.
Publicado: (2023)

Bacterial processing of glucose modulates C. elegans lifespan and healthspan
por: Kingsley, Samuel F., et al.
Publicado: (2021)

Germline burden of rare damaging variants negatively affects human healthspan and lifespan
por: Shindyapina, Anastasia V, et al.
Publicado: (2020)

Healthspan Improvements in Caenorhabditis elegans with Traditional Chinese Herbal Tea
por: Lin, Chunxiu, et al.
Publicado: (2020)

Alzheimer‐related protein APL‐1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans
por: Ewald, Collin Y., et al.
Publicado: (2016)

Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review
por: Knufinke, Marie, et al.
Publicado: (2023)

Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans
por: Stuhr, Nicole L., et al.
Publicado: (2020)

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans
por: Wang, Jing, et al.
Publicado: (2020)

Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans
por: Lenzi, Camille, et al.
Publicado: (2023)

A whole lifespan mouse multi-tissue DNA methylation clock
por: Meer, Margarita V, et al.
Publicado: (2018)

EPIGENETIC PREDICTORS OF LIFESPAN AND HEALTHSPAN
por: Lu, Ake T, et al.
Publicado: (2019)

The Mitochondrial Na(+)/Ca(2+) Exchanger Inhibitor CGP37157 Preserves Muscle Structure and Function to Increase Lifespan and Healthspan in Caenorhabditis elegans
por: García-Casas, Paloma, et al.
Publicado: (2021)

Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan
por: Kawamura, Kazuto, et al.
Publicado: (2019)

The extracellular matrix phenome across species
por: Statzer, Cyril, et al.
Publicado: (2020)

Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7
por: Nguyen, Thuy T., et al.
Publicado: (2016)

Metformin improves healthspan and lifespan in mice
por: Martin-Montalvo, Alejandro, et al.
Publicado: (2013)

An epigenetic biomarker of aging for lifespan and healthspan
por: Levine, Morgan E., et al.
Publicado: (2018)

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
por: Jongsma, Elisabeth, et al.
Publicado: (2023)

A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platelet IRAS/Nischarin (I(1)-Imidazoline Receptor)
por: Keller, Benjamin, et al.
Publicado: (2017)

Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans
por: Kawamura, Kazuto, et al.
Publicado: (2020)

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study
por: Saul, Nadine, et al.
Publicado: (2022)

Protocol for assessing the healthspan of Caenorhabditis elegans after potential anti-aging drug treatment
por: Xiao, Yi, et al.
Publicado: (2023)

Deletion of microRNA-80 Activates Dietary Restriction to Extend C. elegans Healthspan and Lifespan
por: Vora, Mehul, et al.
Publicado: (2013)

Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
por: Matei, Ioan Valentin, et al.
Publicado: (2021)

Autophagy and anti-inflammation ameliorate diabetic neuropathy with Rilmenidine
por: Yalçın, Mehmet Burak, et al.
Publicado: (2023)

Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension
por: Zhang, Bohan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i0flmmd9qpjef3jd2nkhnojjbl