Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization

Vascular amyloidosis, caused when peptide monomers aggregate into insoluble amyloid, is a prevalent age‐associated pathology. Aortic medial amyloid (AMA) is the most common human amyloid and is composed of medin, a 50‐amino acid peptide. Emerging evidence has implicated extracellular vesicles (EVs)...

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Detalles Bibliográficos
Autores principales: Whitehead, Meredith, Yusoff, Syabira, Ahmad, Sadia, Schmidt, Lukas, Mayr, Manuel, Madine, Jillian, Middleton, David, Shanahan, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924949/
https://www.ncbi.nlm.nih.gov/pubmed/36433666
http://dx.doi.org/10.1111/acel.13746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924949/
https://www.ncbi.nlm.nih.gov/pubmed/36433666
http://dx.doi.org/10.1111/acel.13746

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