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Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways

AIMS: Accumulating data demonstrates that new adult cardiomyocytes (CMs) are generated throughout life from pre-existing CMs, although the absolute magnitude of CM self-renewal is very low. Modifying epigenetic histone modifications or activating the Hippo-Yap pathway have been shown to promote adul...

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Detalles Bibliográficos
Autores principales: Zhang, Zhenhe, Freeman, Miles, Zhang, Yiqiang, El-Nachef, Danny, Davenport, George, Williams, Allison, MacLellan, W. Robb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925018/
https://www.ncbi.nlm.nih.gov/pubmed/36780463
http://dx.doi.org/10.1371/journal.pone.0281610