HIV-1 release requires Nef-induced caspase activation

HIV infection remains incurable to date and there are no compounds targeted at the viral release. We show here HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L. Blocking the caspases activation caused virion tethering by CD62L and...

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Detalles Bibliográficos
Autores principales: Segura, Jason, Ireland, Joanna, Zou, Zhongcheng, Roth, Gwynne, Buchwald, Julianna, Shen, Thomas J., Fischer, Elizabeth, Moir, Susan, Chun, Tae-Wook, Sun, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925082/
https://www.ncbi.nlm.nih.gov/pubmed/36780482
http://dx.doi.org/10.1371/journal.pone.0281087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925082/
https://www.ncbi.nlm.nih.gov/pubmed/36780482
http://dx.doi.org/10.1371/journal.pone.0281087

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