PLK1-mediated phosphorylation of β-catenin enhances its stability and transcriptional activity for extracellular matrix remodeling in metastatic NSCLC

Rationale: β-catenin is a component for cell adhesion and a transcriptional coactivator in epithelial-mesenchymal transition (EMT). Previously we found that catalytically active PLK1 drives EMT in non-small cell lung cancer (NSCLC), upregulating extracellular matrix factors including TSG6, laminin γ...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Da-Eun, Shin, Sol-Bi, Kim, Chang-Hyeon, Kim, Yeo-Bin, Oh, Hyun-Ji, Yim, Hyungshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925311/
https://www.ncbi.nlm.nih.gov/pubmed/36793862
http://dx.doi.org/10.7150/thno.79318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925311/
https://www.ncbi.nlm.nih.gov/pubmed/36793862
http://dx.doi.org/10.7150/thno.79318

Ejemplares similares