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PLK1-mediated phosphorylation of β-catenin enhances its stability and transcriptional activity for extracellular matrix remodeling in metastatic NSCLC

Rationale: β-catenin is a component for cell adhesion and a transcriptional coactivator in epithelial-mesenchymal transition (EMT). Previously we found that catalytically active PLK1 drives EMT in non-small cell lung cancer (NSCLC), upregulating extracellular matrix factors including TSG6, laminin γ...

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Detalles Bibliográficos
Autores principales:	Kim, Da-Eun, Shin, Sol-Bi, Kim, Chang-Hyeon, Kim, Yeo-Bin, Oh, Hyun-Ji, Yim, Hyungshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925311/ https://www.ncbi.nlm.nih.gov/pubmed/36793862 http://dx.doi.org/10.7150/thno.79318

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