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Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death

Over half of all cancer patients undergo radiation therapy but there is an unmet need for more efficacious combination strategies with molecular targeted drugs. DNA damage response has emerged as an important intervention point for improving anti-tumor effects of radiation and several inhibitors are...

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Detalles Bibliográficos
Autores principales: Chiu, Li-Ya, Sun, Qing, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925676/
https://www.ncbi.nlm.nih.gov/pubmed/36656721
http://dx.doi.org/10.18632/aging.204487