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Persistent homology analysis distinguishes pathological bone microstructure in non-linear microscopy images

We present a topological method for the detection and quantification of bone microstructure from non-linear microscopy images. Specifically, we analyse second harmonic generation (SHG) and two photon excited autofluorescence (TPaF) images of bone tissue which capture the distribution of matrix (fibr...

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Detalles Bibliográficos
Autores principales: Pritchard, Ysanne, Sharma, Aikta, Clarkin, Claire, Ogden, Helen, Mahajan, Sumeet, Sánchez-García, Rubén J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925777/
https://www.ncbi.nlm.nih.gov/pubmed/36781895
http://dx.doi.org/10.1038/s41598-023-28985-3