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Effects of combinations of gapmer antisense oligonucleotides on the target reduction
BACKGROUND: The co-administration of several therapeutic oligonucleotides targeting the same transcript is a beneficial approach. It broadens the target sites for diseases associated with various mutations or splice variants. However, little is known how a combination of antisense oligonucleotides (...
Autores principales: | Yanagidaira, Mitsugu, Yoshioka, Kotaro, Nagata, Tetsuya, Nakao, Shoichi, Miyata, Kenichi, Yokota, Takanori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925919/ https://www.ncbi.nlm.nih.gov/pubmed/36787053 http://dx.doi.org/10.1007/s11033-022-08224-0 |
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