Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism

Prion diseases are fatal and infectious neurodegenerative diseases that occur in humans and animals. They are caused by the misfolding of the cellular prion protein PrP(c) into the infectious isoform PrP(Sc). PrP(Sc) accumulates mostly in endolysosomal vesicles of prion-infected cells, eventually ca...

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Detalles Bibliográficos
Autores principales: Cherry, Pearl, Lu, Li, Shim, Su Yeon, Ebacher, Vincent, Tahir, Waqas, Schatzl, Hermann M., Hannaoui, Samia, Gilch, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926124/
https://www.ncbi.nlm.nih.gov/pubmed/36623732
http://dx.doi.org/10.1016/j.jbc.2023.102883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926124/
https://www.ncbi.nlm.nih.gov/pubmed/36623732
http://dx.doi.org/10.1016/j.jbc.2023.102883

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