Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male mice

BACKGROUND: Keratitis ichthyosis deafness (KID) syndrome is a rare disorder caused by hemichannel (HC) activating gain-of-function mutations in the GJB2 gene encoding connexin (Cx) 26, for which there is no cure, or current treatments based upon the mechanism of disease causation. METHODS: We applie...

Descripción completa

Detalles Bibliográficos
Autores principales: Peres, Chiara, Sellitto, Caterina, Nardin, Chiara, Putti, Sabrina, Orsini, Tiziana, Di Pietro, Chiara, Marazziti, Daniela, Vitiello, Adriana, Calistri, Arianna, Rigamonti, Mara, Scavizzi, Ferdinando, Raspa, Marcello, Zonta, Francesco, Yang, Guang, White, Thomas W., Mammano, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926223/
https://www.ncbi.nlm.nih.gov/pubmed/36736132
http://dx.doi.org/10.1016/j.ebiom.2023.104453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926223/
https://www.ncbi.nlm.nih.gov/pubmed/36736132
http://dx.doi.org/10.1016/j.ebiom.2023.104453

Ejemplares similares