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Chaperone-assisted selective autophagy targets filovirus VP40 as a client and restricts egress of virus particles
The filovirus VP40 protein directs virion egress, which is regulated either positively or negatively by select VP40–host interactions. We demonstrate that host BAG3 and HSP70 recognize VP40 as a client and inhibit the egress of VP40 virus-like particles (VLPs) by promoting degradation of VP40 via Ch...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926251/ https://www.ncbi.nlm.nih.gov/pubmed/36598950 http://dx.doi.org/10.1073/pnas.2210690120 |