KIF1A is kinetically tuned to be a superengaging motor under hindering loads

KIF1A is a highly processive vesicle transport motor in the kinesin-3 family. Mutations in KIF1A lead to neurodegenerative diseases including hereditary spastic paraplegia. We applied optical tweezers to study the ability of KIF1A to generate and sustain force against hindering loads. We used both t...

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Detalles Bibliográficos
Autores principales: Pyrpassopoulos, Serapion, Gicking, Allison M., Zaniewski, Taylor M., Hancock, William O., Ostap, E. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926277/
https://www.ncbi.nlm.nih.gov/pubmed/36598948
http://dx.doi.org/10.1073/pnas.2216903120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926277/
https://www.ncbi.nlm.nih.gov/pubmed/36598948
http://dx.doi.org/10.1073/pnas.2216903120

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