Distinct dosage compensations of ploidy-sensitive and -insensitive X chromosome genes during development and in diseases

The active X chromosome in mammals is upregulated to balance its dosage to autosomes during evolution. However, it is elusive why the known dosage compensation machinery showed uneven and small influence on X genes. Here, based on >20,000 transcriptomes, we identified two X gene groups (ploidy-se...

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Detalles Bibliográficos
Autores principales: Guo, Mengbiao, Fang, Zhengwen, Chen, Bohong, Songyang, Zhou, Xiong, Yuanyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926305/
https://www.ncbi.nlm.nih.gov/pubmed/36798435
http://dx.doi.org/10.1016/j.isci.2023.105997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926305/
https://www.ncbi.nlm.nih.gov/pubmed/36798435
http://dx.doi.org/10.1016/j.isci.2023.105997

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