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Distinct dosage compensations of ploidy-sensitive and -insensitive X chromosome genes during development and in diseases
The active X chromosome in mammals is upregulated to balance its dosage to autosomes during evolution. However, it is elusive why the known dosage compensation machinery showed uneven and small influence on X genes. Here, based on >20,000 transcriptomes, we identified two X gene groups (ploidy-se...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926305/ https://www.ncbi.nlm.nih.gov/pubmed/36798435 http://dx.doi.org/10.1016/j.isci.2023.105997 |