Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury

Injury to the central nervous system (CNS) provokes an inflammatory reaction and secondary damage that result in further tissue damage and destruction of neurons away from the injury site. Upon injury, expression of connexin 43 (Cx43), a gap junction protein, upregulates and is responsible for the s...

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Detalles Bibliográficos
Autores principales: Chin, Jiah Shin, Milbreta, Ulla, Becker, David L, Chew, Sing Yian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926388/
https://www.ncbi.nlm.nih.gov/pubmed/36798907
http://dx.doi.org/10.1177/20417314221145789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926388/
https://www.ncbi.nlm.nih.gov/pubmed/36798907
http://dx.doi.org/10.1177/20417314221145789

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