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Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA

[Image: see text] Eeyarestatin 24 (ES24) is a promising new antibiotic with broad-spectrum activity. It shares structural similarity with nitrofurantoin (NFT), yet appears to have a distinct and novel mechanism: ES24 was found to inhibit SecYEG-mediated protein transport and membrane insertion in Gr...

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Detalles Bibliográficos
Autores principales: Schäfer, Ann-Britt, Steenhuis, Maurice, Jim, Kin Ki, Neef, Jolanda, O’Keefe, Sarah, Whitehead, Roger C., Swanton, Eileithyia, Wang, Biwen, Halbedel, Sven, High, Stephen, van Dijl, Jan Maarten, Luirink, Joen, Wenzel, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926488/
https://www.ncbi.nlm.nih.gov/pubmed/36637435
http://dx.doi.org/10.1021/acsinfecdis.2c00404