Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

[Image: see text] LasB elastase is a broad-spectrum exoprotease and a key virulence factor of Pseudomonas aeruginosa, a major pathogen causing lung damage and inflammation in acute and chronic respiratory infections. Here, we describe the chemical optimization of specific LasB inhibitors with drugli...

Descripción completa

Detalles Bibliográficos
Autores principales: Everett, Martin J., Davies, David T., Leiris, Simon, Sprynski, Nicolas, Llanos, Agustina, Castandet, Jérôme M., Lozano, Clarisse, LaRock, Christopher N., LaRock, Doris L., Corsica, Giuseppina, Docquier, Jean-Denis, Pallin, Thomas D., Cridland, Andrew, Blench, Toby, Zalacain, Magdalena, Lemonnier, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926489/
https://www.ncbi.nlm.nih.gov/pubmed/36669138
http://dx.doi.org/10.1021/acsinfecdis.2c00418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926489/
https://www.ncbi.nlm.nih.gov/pubmed/36669138
http://dx.doi.org/10.1021/acsinfecdis.2c00418

Ejemplares similares