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Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

[Image: see text] LasB elastase is a broad-spectrum exoprotease and a key virulence factor of Pseudomonas aeruginosa, a major pathogen causing lung damage and inflammation in acute and chronic respiratory infections. Here, we describe the chemical optimization of specific LasB inhibitors with drugli...

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Detalles Bibliográficos
Autores principales:	Everett, Martin J., Davies, David T., Leiris, Simon, Sprynski, Nicolas, Llanos, Agustina, Castandet, Jérôme M., Lozano, Clarisse, LaRock, Christopher N., LaRock, Doris L., Corsica, Giuseppina, Docquier, Jean-Denis, Pallin, Thomas D., Cridland, Andrew, Blench, Toby, Zalacain, Magdalena, Lemonnier, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926489/ https://www.ncbi.nlm.nih.gov/pubmed/36669138 http://dx.doi.org/10.1021/acsinfecdis.2c00418

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