Structural Basis for Cyclosporin Isoform-Specific Inhibition of Cyclophilins from Toxoplasma gondii

[Image: see text] Cyclosporin (CsA) has antiparasite activity against the human pathogen Toxoplasma gondii. A possible mechanism of action involves CsA binding to T. gondii cyclophilins, although much remains to be understood. Herein, we characterize the functional and structural properties of a con...

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Detalles Bibliográficos
Autores principales: Favretto, Filippo, Jiménez-Faraco, Eva, Conter, Carolina, Dominici, Paola, Hermoso, Juan A., Astegno, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926490/
https://www.ncbi.nlm.nih.gov/pubmed/36653744
http://dx.doi.org/10.1021/acsinfecdis.2c00566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926490/
https://www.ncbi.nlm.nih.gov/pubmed/36653744
http://dx.doi.org/10.1021/acsinfecdis.2c00566

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