Subcutaneous Methylnaltrexone as Treatment for Opioid-Induced Constipation in Patients with Advanced Cancer and Noncancer Illnesses: A Post Hoc Analysis of Two Clinical Trials

PURPOSE: To evaluate the efficacy and safety of subcutaneous (SC) methylnaltrexone for opioid-induced constipation (OIC) in patients with and without active cancer. PATIENTS AND METHODS: We analyzed two randomized, double-blind, placebo-controlled, Phase 3/4 trials (NCT00402038, NCT00672477). Patien...

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Detalles Bibliográficos
Autores principales: Shah, Eric D, Chamberlain, Bruce H, Rhiner, Michelle, Slatkin, Neil E, Stambler, Nancy, Israel, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926929/
https://www.ncbi.nlm.nih.gov/pubmed/36798078
http://dx.doi.org/10.2147/JPR.S366460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926929/
https://www.ncbi.nlm.nih.gov/pubmed/36798078
http://dx.doi.org/10.2147/JPR.S366460

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