Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes

TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium–dependent 1A (PPM1A) has been reported as a phosphatase of SMAD2 and regulates TGF-β signaling, while the role of PPM1A in cartilage homeostasis and OA development remains largely unexplored. In this stu...

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Detalles Bibliográficos
Autores principales: Ge, Qinwen, Shi, Zhenyu, Zou, Kai-ao, Ying, Jun, Chen, Jiali, Yuan, Wenhua, Wang, Weidong, Xiao, Luwei, Lin, Xia, Chen, Di, Feng, Xin-Hua, Wang, Ping-er, Tong, Peijian, Jin, Hongting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926971/
https://www.ncbi.nlm.nih.gov/pubmed/36752205
http://dx.doi.org/10.1172/jci.insight.166688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926971/
https://www.ncbi.nlm.nih.gov/pubmed/36752205
http://dx.doi.org/10.1172/jci.insight.166688

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