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Polynucleotide Phosphorylase Mediates a New Mechanism of Persister Formation in Escherichia coli

Despite the identification of many genes and pathways involved in the persistence phenomenon in bacteria, the mechanisms of persistence are not well understood. Here, using Escherichia coli, we identified polynucleotide phosphorylase (PNPase) as a key regulator of persister formation. We constructed...

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Detalles Bibliográficos
Autores principales: Wu, Nan, Zhang, Yumeng, Zhang, Shanshan, Yuan, Youhua, Liu, Shuang, Xu, Tao, Cui, Peng, Zhang, Wenhong, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927094/
https://www.ncbi.nlm.nih.gov/pubmed/36475972
http://dx.doi.org/10.1128/spectrum.01546-22