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The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria

Bacterial defense barriers, such as DNA methylation-associated restriction-modification (R-M) and the CRISPR-Cas system, play an important role in bacterial antimicrobial resistance (AMR). Recently, a novel R-M system based on DNA phosphorothioate (PT) modification has been shown to be widespread in...

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Detalles Bibliográficos
Autores principales: Xu, Congrui, Rao, Jing, Xie, Yuqing, Lu, Jiajun, Li, Zhiqiang, Dong, Changjiang, Wang, Lianrong, Jiang, Jinghong, Chen, Chao, Chen, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927239/
https://www.ncbi.nlm.nih.gov/pubmed/36598279
http://dx.doi.org/10.1128/spectrum.03509-22