Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution

Recently, a new strategy for attenuating RNA viruses by redirecting their evolution in sequence space was confirmed for Enterovirus and Influenza viruses. Using avian flavivirus as a model, the 69 serine and 53 leucine codons on the E-NS1 genes were modified to change evolutionary direction of the v...

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Detalles Bibliográficos
Autores principales: Guo, Jiaqi, He, Yu, Wang, Xiaoli, Merits, Andres, Wang, Mingshu, Jia, Renyong, Zhu, Dekang, Liu, Mafeng, Zhao, Xinxin, Yang, Qiao, Wu, Ying, Zhang, Shaqiu, Huang, Juan, Mao, Sai, Ou, Xumin, Gao, Qun, Sun, Di, Tian, Bin, Cheng, Anchun, Chen, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927255/
https://www.ncbi.nlm.nih.gov/pubmed/36625643
http://dx.doi.org/10.1128/spectrum.02921-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927255/
https://www.ncbi.nlm.nih.gov/pubmed/36625643
http://dx.doi.org/10.1128/spectrum.02921-22

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