PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability

The lack of effective treatment options against Pseudomonas aeruginosa is one of the main contributors to the silent pandemic. Many antibiotics are ineffective against resistant isolates due to poor target site penetration, efflux, or β-lactamase hydrolysis. Critical insights to design optimized ant...

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Detalles Bibliográficos
Autores principales: Montaner, Maria, Lopez-Argüello, Silvia, Oliver, Antonio, Moya, Bartolome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927461/
https://www.ncbi.nlm.nih.gov/pubmed/36475840
http://dx.doi.org/10.1128/spectrum.03038-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927461/
https://www.ncbi.nlm.nih.gov/pubmed/36475840
http://dx.doi.org/10.1128/spectrum.03038-22

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