In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2(R1441G) mutant mouse model of Parkinson's disease

BACKGROUND: Leucine‐rich repeat kinase 2 (LRRK2) mutation is a common genetic risk factor of Parkinson's disease (PD). Presynaptic dysfunction is an early pathogenic event associated with dopamine (DA) dysregulation in striatum of the brain. DA uptake activity of DA uptake transporter (DAT) aff...

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Detalles Bibliográficos
Autores principales: Ho, Philip Wing‐Lok, Li, Lingfei, Liu, Hui‐Fang, Choi, Zoe Yuen‐Kiu, Chang, Eunice Eun Seo, Pang, Shirley Yin‐Yu, Malki, Yasine, Leung, Chi‐Ting, Kung, Michelle Hiu‐Wai, Ramsden, David Boyer, Ho, Shu‐Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927849/
https://www.ncbi.nlm.nih.gov/pubmed/36624932
http://dx.doi.org/10.1002/brb3.2886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927849/
https://www.ncbi.nlm.nih.gov/pubmed/36624932
http://dx.doi.org/10.1002/brb3.2886

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