Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 differentially expressed genes (DEGs) in islets from individ...

Descripción completa

Detalles Bibliográficos
Autores principales: Bacos, Karl, Perfilyev, Alexander, Karagiannopoulos, Alexandros, Cowan, Elaine, Ofori, Jones K., Bertonnier-Brouty, Ludivine, Rönn, Tina, Lindqvist, Andreas, Luan, Cheng, Ruhrmann, Sabrina, Ngara, Mtakai, Nilsson, Åsa, Gheibi, Sevda, Lyons, Claire L., Lagerstedt, Jens O., Barghouth, Mohammad, Esguerra, Jonathan L.S., Volkov, Petr, Fex, Malin, Mulder, Hindrik, Wierup, Nils, Krus, Ulrika, Artner, Isabella, Eliasson, Lena, Prasad, Rashmi B., Cataldo, Luis Rodrigo, Ling, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927941/
https://www.ncbi.nlm.nih.gov/pubmed/36656641
http://dx.doi.org/10.1172/JCI163612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927941/
https://www.ncbi.nlm.nih.gov/pubmed/36656641
http://dx.doi.org/10.1172/JCI163612

Ejemplares similares