Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1–driven fibrotic remodeling in ischemic heart failure

Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify a profibrotic coagulation signaling pathway that can be targeted for...

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Detalles Bibliográficos
Autores principales: Garlapati, Venkata, Molitor, Michael, Michna, Thomas, Harms, Gregory S., Finger, Stefanie, Jung, Rebecca, Lagrange, Jeremy, Efentakis, Panagiotis, Wild, Johannes, Knorr, Maike, Karbach, Susanne, Wild, Sabine, Vujacic-Mirski, Ksenija, Münzel, Thomas, Daiber, Andreas, Brandt, Moritz, Gori, Tommaso, Milting, Hendrik, Tenzer, Stefan, Ruf, Wolfram, Wenzel, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927945/
https://www.ncbi.nlm.nih.gov/pubmed/36548062
http://dx.doi.org/10.1172/JCI156436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927945/
https://www.ncbi.nlm.nih.gov/pubmed/36548062
http://dx.doi.org/10.1172/JCI156436

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