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Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1–driven fibrotic remodeling in ischemic heart failure
Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify a profibrotic coagulation signaling pathway that can be targeted for...
Autores principales: | Garlapati, Venkata, Molitor, Michael, Michna, Thomas, Harms, Gregory S., Finger, Stefanie, Jung, Rebecca, Lagrange, Jeremy, Efentakis, Panagiotis, Wild, Johannes, Knorr, Maike, Karbach, Susanne, Wild, Sabine, Vujacic-Mirski, Ksenija, Münzel, Thomas, Daiber, Andreas, Brandt, Moritz, Gori, Tommaso, Milting, Hendrik, Tenzer, Stefan, Ruf, Wolfram, Wenzel, Philip |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927945/ https://www.ncbi.nlm.nih.gov/pubmed/36548062 http://dx.doi.org/10.1172/JCI156436 |
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