Decoupling the correlation between cytotoxic and exhausted T lymphocyte transcriptomic signatures enhances melanoma immunotherapy response prediction from tumor expression

BACKGROUND: Cytotoxic T lymphocytes (CTL) play a crucial role in anti-cancer immunity. Progression of CTL to terminal exhausted T lymphocytes (ETL) that overexpress inhibitory receptors can substantially decrease effector cytokines production and diminish cytolytic activity and terminal exhausted T...

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Detalles Bibliográficos
Autores principales: Wang, Binbin, Wang, Kun, Jiang, Peng, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928024/
https://www.ncbi.nlm.nih.gov/pubmed/36789444
http://dx.doi.org/10.1101/2023.01.17.524482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928024/
https://www.ncbi.nlm.nih.gov/pubmed/36789444
http://dx.doi.org/10.1101/2023.01.17.524482

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