Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids

Ductal and acinar pancreatic organoids generated from human pluripotent stem cells (hPSCs) are promising models to study pancreatic diseases, including precursor lesions of pancreatic cancer. Genome sequencing studies have revealed that mutations in a G-protein (GNAS(R201C)) are exclusively observed...

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Detalles Bibliográficos
Autores principales: Desai, Ridhdhi, Muthuswamy, Senthil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928035/
https://www.ncbi.nlm.nih.gov/pubmed/36789419
http://dx.doi.org/10.1101/2023.01.16.524220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928035/
https://www.ncbi.nlm.nih.gov/pubmed/36789419
http://dx.doi.org/10.1101/2023.01.16.524220

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