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Conformational free-energy landscapes of a Na(+)/Ca(2+) exchanger explain its alternating-access mechanism and functional specificity
Secondary-active transporters catalyze the movement of myriad substances across all cellular membranes, typically against opposing concentration gradients, and without consuming any ATP. To do so, these proteins employ an intriguing structural mechanism evolved to be activated only upon recognition...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928037/ https://www.ncbi.nlm.nih.gov/pubmed/36789408 http://dx.doi.org/10.1101/2023.01.20.524959 |