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Conformational free-energy landscapes of a Na(+)/Ca(2+) exchanger explain its alternating-access mechanism and functional specificity

Secondary-active transporters catalyze the movement of myriad substances across all cellular membranes, typically against opposing concentration gradients, and without consuming any ATP. To do so, these proteins employ an intriguing structural mechanism evolved to be activated only upon recognition...

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Detalles Bibliográficos
Autores principales:	Marinelli, Fabrizio, Faraldo-Gómez, José D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928037/ https://www.ncbi.nlm.nih.gov/pubmed/36789408 http://dx.doi.org/10.1101/2023.01.20.524959

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