Intravenous functional gene transfer throughout the brain of non-human primates using AAV

Adeno-associated viruses (AAVs) promise robust gene delivery to the brain through non-invasive, intravenous delivery. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood-brain barrier in non-human primates (NHPs). Here we describe AAV.CAP-Mac, an engineered variant identifie...

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Detalles Bibliográficos
Autores principales: Chuapoco, Miguel R., Flytzanis, Nicholas C., Goeden, Nick, Octeau, J. Christopher, Roxas, Kristina M., Chan, Ken Y., Scherrer, Jon, Winchester, Janet, Blackburn, Roy J., Campos, Lillian J., Man, Kwun Nok Mimi, Sun, Junqing, Chen, Xinhong, Lefevre, Arthur, Singh, Vikram Pal, Arokiaraj, Cynthia M., Shaya, Timothy F., Vendemiatti, Julia, Jang, Min J., Mich, John, Bishaw, Yeme, Gore, Bryan, Omstead, Victoria, Taskin, Naz, Weed, Natalie, Ting, Jonathan, Miller, Cory T., Deverman, Benjamin E., Pickel, James, Tian, Lin, Fox, Andrew S., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928057/
https://www.ncbi.nlm.nih.gov/pubmed/36789432
http://dx.doi.org/10.21203/rs.3.rs-1370972/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928057/
https://www.ncbi.nlm.nih.gov/pubmed/36789432
http://dx.doi.org/10.21203/rs.3.rs-1370972/v1

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