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Cell-specific and shared enhancers control a high-density multi-gene locus active in mammary and salivary glands

Regulation of high-density loci harboring genes with different cell-specificities remains a puzzle. Here we investigate a locus that evolved through gene duplication(1) and contains eight genes and 20 candidate regulatory elements, including a super-enhancer. Five genes are expressed in mammary glan...

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Detalles Bibliográficos
Autores principales: Hennighausen, Lothar, Lee, Hye Kyung, Willi, Michaela, Liu, Chengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928059/
https://www.ncbi.nlm.nih.gov/pubmed/36789414
http://dx.doi.org/10.21203/rs.3.rs-2533579/v1