Funneling modulatory peptide design with generative models: Discovery and characterization of disruptors of calcineurin protein-protein interactions

Design of peptide binders is an attractive strategy for targeting “undruggable” protein-protein interfaces. Current design protocols rely on the extraction of an initial sequence from one known protein interactor of the target protein, followed by in-silico or in-vitro mutagenesis-based optimization...

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Detalles Bibliográficos
Autores principales: Tubiana, Jérôme, Adriana-Lifshits, Lucia, Nissan, Michael, Gabay, Matan, Sher, Inbal, Sova, Marina, Wolfson, Haim J., Gal, Maayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928118/
https://www.ncbi.nlm.nih.gov/pubmed/36730443
http://dx.doi.org/10.1371/journal.pcbi.1010874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928118/
https://www.ncbi.nlm.nih.gov/pubmed/36730443
http://dx.doi.org/10.1371/journal.pcbi.1010874

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