Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression

Pharmacological vitamin C (VC) is a potential natural compound for cancer treatment. However, the mechanism underlying its antitumor effects remains unclear. In this study, we found that pharmacological VC significantly inhibits the mTOR (including mTORC1 and mTORC2) pathway activation and promotes...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Senlin, Wang, Guoyan, Chen, Lei, Geng, Huijun, Zheng, Yining, Xia, Chao, Wu, Shengru, Yao, Junhu, Deng, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928125/
https://www.ncbi.nlm.nih.gov/pubmed/36787291
http://dx.doi.org/10.1371/journal.pgen.1010629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928125/
https://www.ncbi.nlm.nih.gov/pubmed/36787291
http://dx.doi.org/10.1371/journal.pgen.1010629

Ejemplares similares