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Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells

T cells develop from multipotent progenitors by a gradual process dependent on intrathymic Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell lineage commitment are well characterized by single-cell and bulk RNA analyses of sorted populations and by direct me...

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Detalles Bibliográficos
Autores principales: Shin, Boyoung, Rothenberg, Ellen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928580/
https://www.ncbi.nlm.nih.gov/pubmed/36817475
http://dx.doi.org/10.3389/fimmu.2023.1108368