TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation

The generation of midbrain dopaminergic neurons (mDAs) from pluripotent stem cells (hPSC) holds much promise for both disease modelling studies and as a cell therapy for Parkinson’s disease (PD). Generally, dopaminergic neuron differentiation paradigms rely on inhibition of smad signalling for neura...

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Detalles Bibliográficos
Autores principales: Sibuea, Shanti, Ho, Joan K., Pouton, Colin W., Haynes, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928866/
https://www.ncbi.nlm.nih.gov/pubmed/36819101
http://dx.doi.org/10.3389/fcell.2023.1111705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928866/
https://www.ncbi.nlm.nih.gov/pubmed/36819101
http://dx.doi.org/10.3389/fcell.2023.1111705

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