Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

Presenilin-1 (PS1) is the catalytic subunit of γ-secretase which cleaves within the transmembrane domain of over 150 peptide substrates. Dominant missense mutations in PS1 cause early-onset familial Alzheimer’s disease (FAD); however, the exact pathogenic mechanism remains unknown. Here we combined...

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Detalles Bibliográficos
Autores principales: Do, Hung N., Devkota, Sujan, Bhattarai, Apurba, Wolfe, Michael S., Miao, Yinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929099/
https://www.ncbi.nlm.nih.gov/pubmed/36788318
http://dx.doi.org/10.1038/s42003-023-04539-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929099/
https://www.ncbi.nlm.nih.gov/pubmed/36788318
http://dx.doi.org/10.1038/s42003-023-04539-1

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