First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors

OBI-999 is a novel antibody-drug conjugate comprising the Globo H–targeting antibody (OBI-888) linked to the cytotoxic payload monomethyl auristatin E. OBI-999 demonstrated excellent dose-dependent tumor growth inhibition in breast, gastric, and pancreatic cancer xenograft models as well as a lung c...

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Detalles Bibliográficos
Autores principales: Tsimberidou, Apostolia Maria, Vo, Henry Hiep, Beck, Jennifer, Shia, Chi-Sheng, Hsu, Pei, Pearce, Tillman E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2023
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929104/
https://www.ncbi.nlm.nih.gov/pubmed/36701651
http://dx.doi.org/10.1200/PO.22.00496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929104/
https://www.ncbi.nlm.nih.gov/pubmed/36701651
http://dx.doi.org/10.1200/PO.22.00496

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