Cargando…

RIIβ‐PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning

The RIIβ subunit of cAMP‐dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. RIIβ‐knockout mice show leanness and increased UCP1 in brown adipose tissue. The authors have previously reported that RIIβ reexpression in hypothalamic GABAergic neurons rescues the leanness. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Bingwei, Zhao, Miao, Su, Zhijie, Jin, Baohua, Yang, Xiaoning, Zhang, Chenyu, Guo, Bingbing, Li, Jiebo, Hong, Weili, Liu, Jiarui, Zhao, Yun, Hou, Yujia, Lai, Futing, Zhang, Wei, Qin, Lihua, Zhang, Weiguang, Luo, Jianyuan, Zheng, Ruimao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929258/ https://www.ncbi.nlm.nih.gov/pubmed/36529950 http://dx.doi.org/10.1002/advs.202205173

Ejemplares similares

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

Celastrol prevents high‐fat diet‐induced obesity by promoting white adipose tissue browning
por: Wang, Bingwei, et al.
Publicado: (2021)

The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease
por: Zhang, Chenyu, et al.
Publicado: (2021)

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
por: Zhang, Ping, et al.
Publicado: (2015)

Leptin signaling and leptin resistance
por: Liu, Jiarui, et al.
Publicado: (2022)

The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease
por: Zhao, Miao, et al.
Publicado: (2021)

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination
por: Isensee, Jörg, et al.
Publicado: (2018)

Dissociation between AKAP3 and PKA(RII) Promotes AKAP3 Degradation in Sperm Capacitation
por: Hillman, Pnina, et al.
Publicado: (2013)

Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats
por: Chan, Owen, et al.
Publicado: (2011)

GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice
por: Murata, Koshi, et al.
Publicado: (2019)

PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser(114) phosphorylation
por: Weigand, Isabel, et al.
Publicado: (2021)

Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70
por: Ding, Cui-Ling, et al.
Publicado: (2015)

GABAergic neurons in the dorsomedial hypothalamus regulate states of consciousness in sevoflurane anesthesia
por: Wang, Yanfeng, et al.
Publicado: (2022)

A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types
por: Campbell, John N., et al.
Publicado: (2017)

Association between Take-Out Food Consumption and Obesity among Chinese University Students: A Cross-Sectional Study
por: Jiang, Yuhe, et al.
Publicado: (2019)

Involvement of GABAergic and Adrenergic Neurotransmissions on Paraventricular Nucleus of Hypothalamus in the Control of Cardiac Function
por: Mendonça, Michelle M., et al.
Publicado: (2018)

Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes
por: Sun, Yanrong, et al.
Publicado: (2022)

Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei
por: Xu, Zhengchao, et al.
Publicado: (2021)

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination
por: Garcia, Neus, et al.
Publicado: (2019)

Role of Dorsomedial Hypothalamus GABAergic Neurons in Sleep–Wake States in Response to Changes in Ambient Temperature in Mice
por: Li, Lei, et al.
Publicado: (2022)

Neural adaption in midbrain GABAergic cells contributes to high-fat diet–induced obesity
por: Wang, Xiaomeng, et al.
Publicado: (2023)

GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin
por: Yonemochi, Naomi, et al.
Publicado: (2019)

Activity and Coupling to Hippocampal Oscillations of Median Raphe GABAergic Cells in Awake Mice
por: Jelitai, Marta, et al.
Publicado: (2021)

Clinical Implications of TβRII Expression in Breast Cancer
por: Gao, Ningning, et al.
Publicado: (2015)

Optogenetic/Chemogenetic Activation of GABAergic Neurons in the Ventral Tegmental Area Facilitates General Anesthesia via Projections to the Lateral Hypothalamus in Mice
por: Yin, Lu, et al.
Publicado: (2019)

GABAergic neurons in the nucleus accumbens regulate hedonic food intake via orexin-A expression in the lateral hypothalamus
por: Kong, Jieting, et al.
Publicado: (2021)

Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons
por: Marino, Rosa Anna M., et al.
Publicado: (2020)

Optogenetic activation of leptin- and glucose-regulated GABAergic neurons in dorsomedial hypothalamus promotes food intake via inhibitory synaptic transmission to paraventricular nucleus of hypothalamus
por: Otgon-Uul, Zesemdorj, et al.
Publicado: (2016)

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma
por: Lu, Tsan-Wen, et al.
Publicado: (2020)

GABAergic modulation of noradrenaline release caused by blood pressure changes in the rat median preoptic area
por: Takahashi, Makoto, et al.
Publicado: (2017)

GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB(1) Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus
por: Reguero, Leire, et al.
Publicado: (2011)

A Very Large Number of GABAergic Neurons Are Activated in the Tuberal Hypothalamus during Paradoxical (REM) Sleep Hypersomnia
por: Sapin, Emilie, et al.
Publicado: (2010)

Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention
por: Martín-López, Juana, et al.
Publicado: (2017)

NCOR1/2 loss of function impairs memory through a novel GABAergic hypothalamus–CA3 projection
por: Zhou, Wenjun, et al.
Publicado: (2019)

Novel median thoracic expansion for asphyxiating thoracic dystrophy
por: Wang, Wenlin, et al.
Publicado: (2022)

Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus
por: Jang, Yunseon, et al.
Publicado: (2021)

Expression and function of FcγRII on NK cells in rhesus macaques
por: He, X, et al.
Publicado: (2012)

Decreased expression of FcγRII in active Graves' disease patients
por: Lu, Xixuan, et al.
Publicado: (2019)

Genetic Diversity, Natural Selection and Haplotype Grouping of Plasmodium knowlesi Gamma Protein Region II (PkγRII): Comparison with the Duffy Binding Protein (PkDBPαRII)
por: Fong, Mun Yik, et al.
Publicado: (2016)

Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits
por: Roa, Jinae N., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rhdp7lqiqvhkbr665hvfriqra6